PhD position in advanced MRI of Sickle Cell Disease

PhD position in advanced MRI of Sickle Cell Disease

Website amsterdamumc Amsterdam University Medical Center, location AMC

A 4-year PhD position is available in the departments of Radiology and Nuclear Medicine and Hematology at Amsterdam University Medical Center, location AMC. Sickle Cell Disease (SCD) is a hereditary hemoglobinopathy that causes red blood cells to form a sickle shape in a deoxygenated state. Chronic hemolytic anaemia and vascular occlusion are symptoms of the disease. The prevalence of silent stroke in SCD is high, and there is no test to assess the risk of silent stroke in SCD. SCD pathophysiology in the brain can now be studied using advanced imaging technology such as magnetic resonance imaging (MRI). Over the last decade, the AMC group has established a strong research line in sickle cell disease imaging, employing both arterial spin labelling and 4D flow MRI to assess cerebrovascular impairment.

In this role you will have access to cutting-edge imaging hardware and software developed by the group. On a global scale, you will work with several research groups on this topic, most notably Children’s Hospital Los Angeles (CHLA). A medical PhD student has been appointed to the same project and you will work closely together.

The goal of this PhD project is to investigate if imaging biomarkers can predict stroke in patients with SCD

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