Phd position intramuscular injections for treatment of Duchenne muscular dystrophy

Phd position intramuscular injections for treatment of Duchenne muscular dystrophy

  • Full Time
  • Leiden

Website mri_lumc Leiden University Medical Center, C.J. Gorter MRI Center, Department of Radiology

Patients with Duchenne muscular dystrophy lack muscle dystrophin protein causing severe muscle weakness, loss of mobility at an early age and respiratory or heart failure resulting in premature death. Our ambition is to realize a first proof-of-concept clinical trial in the next five years. To realize this ambition, we are building a team of researchers, physicians and clinical researchers, regulatory experts, pharmacologists and toxicologists. As a (physician) researcher at the Radiology department, you will conduct high-quality research into the administration of our CRISPR-Cas-based gene-modification technology for the treatment of DMD patients. Up to now, CRISPR-Cas is not used clinically, making this project challenging and potentially groundbreaking. You will develop the method for intramuscular administration for the intended gene-editing therapy and investigate monitoring methods. This will include the development of an injection method that enables homogeneous treatment of an entire muscle in a controlled and reproducible manner. You will establish if ultrasound or MRI is the optimal method to achieve this goal. There is space within the project for more general studies into development and evaluation of MRI techniques including MR guided intervention for patient care.  In collaboration with other (physician) researchers, regulatory and safety experts in the team, you will perform preparatory work for an intended Phase I/II clinical study. If it fits within the duration of the appointment, you will of course also play a key role in setting up the intended clinical trial. Finally, you are part of the international reNEW consortium and you participate in national and international conferences by presenting the data on the basis of posters and oral presentations. Your work will eventually lead to a clinical plan of action.

We are looking for a passionate (physician) researcher, technical physician, biomedical technologist or human movement scientist with an affinity for muscle diseases in children and young adults and the technical aspects of therapeutic administration and monitoring. Excellent communication skills and enthusiasm for multidisciplinary collaboration are essential. You can work independently and are interested in developing new intramuscular administration methods and techniques to monitor administration. You are social, communicative and flexible. The research team is international and a good command of English, both written and oral, is important.

For more information you can contact Mark Burgmans, head of Intervention Radiology, Radiology department, e-mail: m.c.burgmans@lumc.nl or Hermien Kan, vice-director C.J. Gorter MRI Center, Radiology department, email: h.e.kan@lumc.nl

 

To apply for this job please visit www.lumc.nl.