Postdoc on in vitro/ex vivo MRI at ultra-high field

Postdoc on in vitro/ex vivo MRI at ultra-high field

Website Wageningen University & Research

  • Do you want to do pioneering work on state-of-the-art high-/ultra-high-field NMR spectrometers?
  • Are you interested in developing and optimizing NMR/MRI microimaging acquisition methods for ultra-high resolution of pre-clinical studies?
  • Do you want to use your passion for supporting advanced MRI applications and work in a wide national network?

We invite applications for a post-doctoral position of 1 year, with possibility of extension to 2 years depending on performance, based at the Laboratory of Biophysics at Wageningen University (WU). The work is in close collaboration with partners within two national consortia, respectively Utrecht University (UU) and the University Medical Center (UMC) of Utrecht within the Dutch NMR consortium (uNMR-NL), and the 4 Technical Universities (4TU) in The Netherlands involved in the “Precision Medicine” program.

The focus of this position is on the implementation of microimaging methods at high-/ultra-high-field NMR spectrometers (14-28T), to boost sensitivity, spatial and chemical resolution in pre-clinical MRI studies of small-volume soft biological materials and living systems, such as cell cultures. The goal of this collaborative project is to achieve cellular-level and microstructural information, not accessible at lower/intermediate magnetic fields, to ultimately aid more accurate identification of early and diffuse microscopic tissue alterations.

The challenges of this post-doc position lie in the implementation and optimization of some MRI pulse sequences (e.g. CEST imaging, susceptibility-weighted imaging, imaging with X-nuclei, MR spectroscopy, multi-dimensional qMRI, etc) for high-to-ultra-high field applications. This position will cover both method developments and related applications in the field of pre-clinical MRI, with due focus on troubleshooting and optimizing experimental conditions for MRI measurements at ultra-high magnetic fields. The work will be carried out using a new WB 600 MHz (14 T) spectrometer recently installed at WU in 2022, a SB 950 MHz (22 T) spectrometer at RU, and the first 1.2 GHz (28 T) spectrometer with micro-imaging capabilities worldwide, recently installed at UU. As post-doc, you will be based in Wageningen, though we expect you to travel to other universities in the consortium to use the right available equipment, as well as to cooperate with other post-docs deployed within the uNMR-NL consortium.

The position is intended to be filled latest by September 1st 2022.

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